The objective of the present investigation was to propose a solution to the excessive generation of waste in a Peruvian SME dedicated to the production of sweet arare, combining both the Systematic Layout Planning (SLP) and the Lean Manufacturing 5S methodologies. The SLP methodology was used to optimize the distribution of the plant according to the production process and the 5S methodology proposed specific improvements at each of its stages. Through a simulation in the Arena software, it was validated that this solution reduces the proportion of waste produced to competitive levels in the industry, in addition to minimizing the material handling distance by 43.77% and the material transfer time by 8.75%.