The transportation of hazardous materials and valuables, exemplified by cash-in-transit, poses significant risks. Valuables transportation is prone to robbery, while hazmat transport faces accidents and potential material release, endangering the populace and the environment. This paper emphasizes the importance of researching risk mitigation in this domain, highlighting recent scholarly insights. It identifies research gaps, including the need for enhanced risk assessment models and the consideration of multimodal transportation. The manuscript advocates for interdisciplinary collaboration and innovative methodologies to fortify route security and minimize risks in CIT and hazmat transportation.