An attractive reward system promotes academic staff engagement which impacts on an organisation’s ability to acquire, retain and motivate high potential employees and ultimately attaining higher levels of performance. The primary goal of this paper is to explore the impact of reward system on employee engagement and organizational performance in selected Technical Universities (TUs) in Ghana. To achieve this objective, data was collected using Google forms from 31 academic staff working at 6 selected TUs. Data was captured in SPSS version 27, and analyzed using descriptive statistics, multiple linear regression, and structural equation model. The findings of the study reveal that reward system (RS) has a significant effect on employee engagement (EE) and predicts organisational performance (OP) while EE significantly predicts OP. Additionally, RS significantly mediates EE and OP for the selected Technical Universities in Ghana. In the light of these findings, organizational reward system and academic staff engagement are critical human resource factors for improving the performance of the selected institutions sampled. The outcome of this research calls for the policy makers and the TUs management to consider reward system and academic staff engagement programs as tools for addressing the current challenges facing the sector. The study contributes significantly to the knowledge and application of RS, EE and OP in theory and practice in the context of higher education sector.