Improving sustainability performance across the Triple Bottom Line (TBL), which encompasses social, environmental, and economic aspects, is crucial for companies operating in the manufacturing sector. Particularly in countries with emerging economies, there is a significant demand for responsible and sustainable business practices. Using a Thai manufacturing company case study, this study investigates the synergies and trade-offs among TBL dimensions. Additionally, the study explores the impact of Industry 4.0 technologies and Circular Economy (CE) practices on these synergies and trade-offs. A qualitative method, specifically a semi-structured interview, was adopted in this study. The findings indicate that the performance of economic and environmental dimensions is more tangible when compared to social performance. The manufacturing company recognizes the long-term benefits of improving TBL performance. Our study explains how adopting Industry 4.0 technologies and CE practices improves sustainability. The outcomes of this research can serve as valuable inputs for industrialists and practitioners, assisting manufacturing companies in improving and balancing their TBL performances.