Delivering value to the consumer, allocating orders, and cost-optimization are all functions that the retail distribution supply chain performs with growing importance. As a result, businesses must embrace a comprehensive perspective of the entire network. These requirements have driven the modeling of supply chain network design from a retail standpoint. The study considers a multi-echelon network with several manufacturers, distributors, retailers, and customers while developing a mathematical model to minimize total costs. In addition, it uses secondary data from a Small and Medium-sized Enterprise in Vietnam, called the SME to improve its network. The findings are used for strategic and operational decisions, such as determining the number of facilities needed, optimizing total distribution costs, as well as resulting in a need for a strategic alliance. To our knowledge, this empirical study is one of the efforts to provide the door for more research on the adoption of a retail distribution supply chain network design.