The intertwine between work demand (WD) and job autonomy (JA) as antecedent factors has long been subject to discussion with each new finding provides insights in balancing employee performance and well-being, especially in the short term. However, research on employee sustainable performance (ESuPer) with WD and JA as influencing factors has yet properly researched both quantitatively and qualitatively. Digital leadership (DL) on the other hand has becoming household jargon in the era of Industry 4.0 indicating the trend of leadership has already shifted into the facilitation of a more data-driven, flexible time, people-oriented, collaborative, and technology-savvy working environment. However, the moderation of DL within WD and JA towards ESuPer has not been addressed sufficiently. The goal of this paper is to propose theoretical foundation for the nexus of WD, JA, ESuPer, and DL, thus presenting a complete review of the references on the interdependence association of WD, JA, ESuPer, and DL. This paper provides insights for researchers as well for managers on what variables need to be considered when it comes to approximately similar interdependence.