Industrial engineering science is developing rapidly with an increasingly broad object of study, richer methods and an increasingly large role in various fields. The development of industrial engineering always synergizes with other scientific and engineering disciplines (especially in the field of automation). Industrial engineering science has been proven to have a role in giving birth to the Industry 4.0 phenomenon. Despite all the advantages and conveniences that will be provided by Industry 4.0, there are still negative consequences and impacts that must be faced. No exception to the science of industrial engineering itself. This is where the challenge of industrial engineering science is to continue to study and develop its scientific field. Even though there are influences from changing times and other scientific developments, industrial engineering should retain its uniqueness, namely the focus on studying human interaction with various other components in integrated systems in industry. It is hoped that in the future, industrial engineering can have a role in directing the Industrial 4.0 era to the advancement of science that provides great value for humanityIndustrial engineering science is developing rapidly with an increasingly broad object of study, richer methods and an increasingly large role in various fields. The development of industrial engineering always synergizes with other scientific and engineering disciplines (especially in the field of automation). Industrial engineering science has been proven to have a role in giving birth to the Industry 4.0 phenomenon. Despite all the advantages and conveniences that will be provided by Industry 4.0, there are still negative consequences and impacts that must be faced. No exception to the science of industrial engineering itself. This is where the challenge of industrial engineering science is to continue to study and develop its scientific field. Even though there are influences from changing times and other scientific developments, industrial engineering should retain its uniqueness, namely the focus on studying human interaction with various other components in integrated systems in industry. It is hoped that in the future, industrial engineering can have a role in directing the Industrial 4.0 era to the advancement of science that provides great value for humanityIndustrial engineering science is developing rapidly with an increasingly broad object of study, richer methods and an increasingly large role in various fields. The development of industrial engineering always synergizes with other scientific and engineering disciplines (especially in the field of automation). Industrial engineering science has been proven to have a role in giving birth to the Industry 4.0 phenomenon. Despite all the advantages and conveniences that will be provided by Industry 4.0, there are still negative consequences and impacts that must be faced. No exception to the science of industrial engineering itself. This is where the challenge of industrial engineering science is to continue to study and develop its scientific field. Even though there are influences from changing times and other scientific developments, industrial engineering should retain its uniqueness, namely the focus on studying human interaction with various other components in integrated systems in industry. It is hoped that in the future, industrial engineering can have a role in directing the Industrial 4.0 era to the advancement of science that provides great value for humanity