Electronic device thermal management has long been a fascinating subject to study. All electronic equipment generates excessive heat, which needs to be removed for better performance. Due to their superior heat transfer capability, efficiency, and structural simplicity, heat pipes stand out as the most suitable technological and thermally efficient option. Higher heat flux is crucial in numerous technical applications. Modern heat control for microelectronics can be accomplished with multiphase passive devices. In this paper, the attempt will be to discuss the properties of closed loop pulsing heat pipes (CLPHP), a novel member of the closed passive two-phase heat transfer system family. The goal of the current study is to investigate the relationship between thermal performance and filling ratios and comparative thermal performance analysis of heat pipes for plain tube and wire insert setup. Acetone was used as the working fluid for both setups. The multiturn copper tube has an inner and outer diameter of 2.12 mm and 3.1 mm, respectively. Regarding the CLPHP with insert setup, a wire with a 1 mm diameter is placed inside a copper tube of 3.49 m in length. The heat pipe was divided into three parts: evaporator, adiabatic zone, and condenser. Each CLPHP has an electrically heated evaporator and condenser with a fixed length. Adiabatic zone is made to be insulated so that no heat can be transferred. For experimenting, from 15% filling ratio to 90% filling ratio with a 25% increment, temperatures of the evaporator, adiabatic zone, and condenser were recorded. Results showed how system performance varied with various filling ratios and heat inputs. Heat transfer characteristics of the wire insert in PHP for a closed loop were investigated, and the experimental findings were then compared with those of a PHP configuration using a plain tube while maintaining the other parameters constant. Considering two setups, for 40% and 65% filling ratios in the wire insert setup of Acetone were found to be the most optimum thermal performance. The thermal performance of the CLPHPs is dependent on the conjugation effects of the working fluid, filling ratio, wire effect, and heating power input, according to experimental results for both setups. According to the findings, it may be possible to insert a closed loop pulsing heat pipe into a structure and further analyze the more efficient heat pipe between plain tube and wire insert setup with different filling ratios to increase thermal conductivity to the host substrate.