Shear walls are basically provided to resist lateral loads and the role of a shear wall is to provide the stiffness for resisting those loads and provide an effective approach to stiffen a building structural system. Sometimes openings in shear wall for doors, windows, and other purposes are required. Depending on the function of the openings, the size and position of the openings may vary. Shear wall is a RC structural element resists lateral loads, majorly due to wind and seismic loads. The aim of the given study is to know the response of shear walls for 5 to 40 story RC frame structures provided with different percentages of openings. Equivalent static method of seismic analysis in staad pro is performed to collect the data set for 240 models in terms of Base Shear. Also, Machine learning techniques is being applied to predict the Base Shear models within the given range. The analysis data can be further used directly as modelling of shear walls in staad pro requires a lot of effort, time, and practice, so this predicted model will simply help us to predict the seismic response in terms of base shear of any similar RC Frame structures provided with shear walls and various percentages of openings.