Social enterprise towards community empowerment are commonly developed as poverty alleviation strategies by combining community, corporates, and government strengths and initiatives. The development of social enterprise in Indonesia has rapidly grown over recent years. In the middle of covid-19 pandemic influences the uncertainty condition to keep the business able to survive. In this disadvantaged situation, many social enterprise organizations face vulnerability situations regarding problems and challenges that occurred. However, some social enterprises can survive by facing the challenges into opportunities. Thus, developing some strategies becomes the best choice for resilience. The study conducts a qualitative method by focusing on in-depth interviews by using interviews, literature studies, and social media documentation. This study aims to describe the challenges, opportunities, and strategies of the best practices from three social enterprise organizations in Indonesia. The finding reveals that multi-stakeholders including government, higher education institutions, media, other companies, and local communities finally able to encourage the social enterprise organizations in formulating and implementing the strategies to strengthen their resilience during the pandemic.