This study analyzes the influence of Human Resource Management and the Work Environment on Performance through the Quality of Human Resources at the Regional Secretariat of Bantaeng Regency, both directly and indirectly. The research was conducted at the Regional Secretariat Office of Bantaeng Regency, withdrawing samples using the saturated sample technique. Obtained a selection of 106 employees of the Regional Secretariat who were research respondents. To get the data used the interview method and distributed questionnaires according to research needs. Data analysis was performed using path analysis. This research resulted in (1) the positive and significant influence of human resource management and the work environment on the quality of human resources. (2) Human resource management, work environment, and quality of human resources have a positive and significant effect directly on the performance of employees at the Regional Secretariat of Bantaeng Regency. (3) Human resource management has a positive and significant effect on employee performance through the quality of human resources, and (4) the work environment has a positive and significant effect on employee performance through the quality of human resources at the Regional Secretariat Bantaeng Regency.