Known as the region which has highest added value in East Java, Indonesia, Mojokerto Regency has a potential leading economic sector for regional development. During the Covid-19 pandemic, Mojokerto experienced a contraction of 1.11 per cent in 2020 then recovered rapidly by 5.15 percent in 2021. This growth was driven by the development of the particular economic sectors of the Mojokerto Regency. This study aims to analyse the leading and potential sectors in Mojokerto Regency using Location Quotient, Overlay, and Shift Share analysis methods. In comparing the trend before and during the pandemic, this study calculates the data of Gross Domestic Regional Product (GDRP) published by Indonesian Statistic Agency from 2018 to 2021.  According to the empirical calculation, the manufacturing sector is a potential leading sector and has the most significant contribution to the GRDP of Mojokerto Regency followed by information and communication and government administration. Tourism sectors measured by accomodation, food and beverage industry were the sector which experienced the drawbacks from Covid-19 pandemic. In boosting the sectoral competitiveness, stakeholders should colloborate in enhancing the rapid recovery especially for tourism which exhibited lower growth during the crisis.