This study aims to examine the influence of burnout and self-efficacy on career satisfaction, with work-life balance serving as a mediating variable among banking employees in Indonesia. Burnout is a significant issue in the banking sector, leading to decreased employee productivity and well-being. Conversely, self-efficacy, or an individual's belief in their ability to complete tasks, can enhance job performance and career satisfaction. Work-life balance is considered a crucial factor that can influence both burnout and self-efficacy. The research employed a quantitative approach through a survey of 163 respondents from various banks across Indonesia. Data were collected using a questionnaire designed to measure burnout, self-efficacy, work-life balance, and career satisfaction. The analysis was conducted using Structural Equation Modeling (SEM) with the Partial Least Squares (PLS) approach, utilizing the SmartPLS software. The results show that burnout has a significant negative impact on career satisfaction, while self-efficacy has a significant positive effect. Furthermore, work-life balance plays a significant mediating role between burnout and career satisfaction, as well as between self-efficacy and career satisfaction. Employees who manage to maintain a healthy work-life balance are likely to experience lower levels of burnout and higher self-efficacy, which ultimately enhances their career satisfaction. These findings have practical implications for bank management in developing strategies to improve employees' work-life balance, such as offering flexible work hours and employee wellness programs. Thus, organizations can create a healthier and more productive work environment that enhances overall employee career satisfaction and performance.