Business start-ups are companies that have not been operating for a long time. These companies are mostly newly founded companies and are in the development and research phase to find the right market in the technology. Such conditions have an impact on the long process of business start-ups to develop their businesses which have a high risk of failure if the process is not followed by the right method to develop their business. Several business concepts are used by start-up companies to help develop their business such as the Model Business Canvas (MBC). On the other hand, knowledge management system is a type of IT system that stores and retrieves knowledge to improve understanding, collaboration, and alignment of processes that can be utilized by business start-ups to develop their businesses by managing their knowledge and using Knowledge Management Systems to help them make business decisions. Thus, the purpose of this research is to help business start-ups manage their knowledge by combining the concepts of validated learning and knowledge management systems to develop their businesses. The research method uses a qualitative approach through observation of business start-ups to identify their business problems. Meanwhile, literature review is used to find alternative solutions using the business development concept that has been used by many companies, namely MBC.