The increase in the competitive business environment forces business actors to maintain their position in the market. This study aims to examine the effect of the technology acceptance model, manager competence, and enterprise risk management on competitive advantage: mediating role by e-commerce adoption and moderating role by financial literacy. This study involved 100 business actors who were selected using the probability sampling technique. Data was obtained by distributing questionnaires to respondents through the G-Form. The collected data is then analyzed using Path analysis assisted by the Smart PLS application. Based on the research results, it is known that E-Commerce adoption, TAM, Manager Competence, and ERM have a significant positive effect on competitive advantage. The variables TAM, Manager Competence, and ERM were found to have a significant positive effect on e-commerce adoption. Meanwhile, Financial Literacy is only able to moderate the relationship between Manager Competence and E-Commerce adoption and has not been able to moderate the relationship between TAM and ERM to E-Commerce adoption. In addition, the researchers also found that Competitive Advantage was able to mediate the relationship of TAM, Manager Competence, and ERM to competitive advantage. Business owners are expected to be able to disclose enterprise risk management (ERM) and develop quality human resources on an ongoing basis so that the company can win the market competition.