Software as a Service (SaaS)-based academic information system has become a new trend in system procurement in universities, particularly in Indonesia. With the various advantages of SaaS-based academic information system, many universities have finally chosen to switch to this service model. The paper examines the factors influencing college student acceptance toward SaaS-based academic information systems with an extended UTAUT model with Trust and Quality of Service (QoS). Data were collected from 338 college students and analyzed with Generalized Structured Component Analysis (GSCA). This study reveals that the significant predictor of SaaS-based academic information systems is performance expectancy, effort expectancy, social influence, and facilitating condition. Further result and discussions are discussed.