The focus on climate change in recent decades has promoted an awareness of the need for renewable, clean energy. Used as a supplement to conventional diesel, biodiesel has been shown to be a viable option to decrease dependency on nonrenewable petroleum products while reducing air pollutants. Biodiesel precursors can be extracted and refined from renewable resources such plants, vegetables and animal fats. Transesterification of these natural oils and fats is the method of choice for producing biodiesel. Significant work has been completed in carrying out the reaction in a variety of reactors however limited simulations of the reaction have been completed due to the complexity of simulating a multiphase reacting system. This study focuses on maximizing the yield of microfluidic biodiesel production through the use of microreactors. The objective of the study was to build a COMSOL model of the multiphase biodiesel reaction and to evaluate various 2D microreactor designs. Based on these results, an optimal design was to be recommended.