Moving and treating wastewater is energy intensive and often ignored during the wastewater treatment plant operation process due to the main emphasis on water quality. In this research, one of the most energy intensive processes of wastewater treatment, namely aeration process is optimized with consideration of water quality as well as energy aspects. The computational models developed in the present research indicate with less energy consumption, still an acceptable water quality level can be achieved. Case studies depicting few energy saving scenarios are also investigated.