This experimental study investigated the relationship between scan speed, point density, outlier elimination, probe diameter, probing force, filtration, part location in the measuring envelope of a CMM, and part orientation in the CMM. The goal of this investigative study was not only to find the best optimal combination of the factors but also to determine factor levels in CMM that influence cylindricity measurement. The results of the CMM measurements were compared with FAG (a reference form measuring machine) and verified the CMM capability and accuracy of measuring the cylinder bore geometry. A quarter fraction experimental design with 64 runs was conducted to gain knowledge among all factors. A confirmatory run was performed to validate the findings.