This main focus of this paper is to assess the effect of globalization on total factor productivity (TFP) performance of the Pakistan’s manufacturing sector. The study was inspired because of the requirement to analyze the effect of globalization on the TFP estimates of the manufacturing sector. In this paper, the overall effect on globalization is construed by considering the variables that represent globalization of economy. These encompass capital intensity, foreign investment, high technology content in sector, labor force, value added (output) by sector, openness of the economy and the sector contribution to GDP growth. This study utilizes data from Federal Bureau of Statistics (FBS), Economic Surveys (ES), State Bank of Pakistan (SBP), Census of Manufacturing Industries (CMI) and Asian Productivity Organization (APO) which cover the period from 1990 to 2013. The data is analyzed using descriptive statistics, Philips Peron unit root test and panel regression models on SPSS and EViews. The findings show that the capital intensity, value added (output) and openness of economy are significant variables when considering their descriptive statistics and positively contribute to the TFP of the Pakistan’s manufacturing sector. Alternatively, high technology content agreements and foreign direct investment are not significant as per statistical analysis. Together these two factors do not constitute as much to the positive impact of TFP in the manufacturing sector.