2D barcode can be found on the largely product in the department store. The purpose of 2D barcode is generally used to identify basic product information. In the industrial application has a 2D barcode in the assembly production line. The use of both a characteristic of the 2D barcode can be easily copied. In this paper, 2D barcode encrypted with multi-encryption technique, difficult to replicate and reproduce. The decoding system is read 2D barcode encoding only and can be record 2D barcode when the repeat of 2D barcode are found. This research has led to real benefits, which can be inhibited to prevent commercial use of 2D barcode in Thailand.