The paper introduces one new approach to optimize the design of Lean supply chain under uncertain scenarios by hybrid meta-heuristics. The main purpose of this study is to figure out some potential measures which can keep Lean supply chain both Lean and sustainable in chaos environment nowadays. First of all, we propose one theoretical framework to transform fat supply chain into Lean supply chain in neutral circumstance. The framework utilizes suitable Lean tools/techniques to eliminate non-added-value factors of supply chain and makes it lean. Nevertheless, when becoming Lean, the supply chain turns out vulnerable system under threats because there is no/very less available backup for any unexpected shortages. Thus, to maintain its sustainability, in next step, we investigate the effects of multi-risks sources occurring from reality on Lean supply chain structure. From then, we propose some necessary contingency plans to quickly response the unpredicted problems and mitigate the consequences. All of prepared plans are examined and integrated into the design stage. Finally, the aforementioned issue is then illustrated in detail through one numerical example and resolved by a hybrid meta-heuristics.