Milling section is a heart of sugar industry. In one of the State of the Art sugar Industry of Pakistan, the moisture content in Last Mill Baggase poll (milling) rose higher up to 51.5%, resulting in troublesome situation. LSS in conjugation with DMAIC technique is executed to obtain optimal settings for major significant factors, contributing in the escalation of moisture. Keeping in view the massive sophisticated processes involved in sugar industry, response surface optimization technique was deployed following the regression analysis, resulted in the saving of overall 4.5 Million PKR per annum.