Nowadays, new conjunctions between communication technologies and devices in the health care context, and between health and social care, create important opportunities concerning the development of frameworks and devices/interoperable systems (eHealth systems), particularly in the ever increasingly Remote Patient Monitoring (RPM) systems environment. However most of users’ needs and requirements are not really satisfied with a poor customization of solutions in according to specific cluster of users. This is mainly due to a lack of truly interoperable tools that allow a horizontal integration between the various medical / specialized tools and utilities. This paper introduces an effective conceptual framework to manage the many stakeholders connected to the development of RPM solutions.