Economic development is done to achieve economic growth of a country. Unplanned economic development has a negative impact on environmental damage. The dynamics of economic growth and population is very potential for global warming caused by the accumulation of CO2 emissions in the air. This paper intends to investigate the effect of economic and population growth in increasing CO2 emissions in the air. The goal is to estimate the models that are able to illustrate the relationship between economic growth and the population towards the changes in CO2 emissions in the air. Model estimation is done by using product function in Cobb-Douglas, meanwhile parameter estimation is done by using ordinary least square method (OLS). The results of the analysis show that the Cobb-Douglas production function can significantly illustrate the relationship of economic and population growth influence to CO2 emission change. The strength of the relationship can be shown by the coefficient of determination which reached 98.0% This shows the truth that the increase in CO2 emissions is significantly influenced by economic growth and population.