Drivers' safety awareness is known to contribute to the integrity of transportation companies. However, for intercity bus drivers, the process of building safety awareness is challenging. Therefore, this research aims to determine other variables that significantly affect drivers' safety awareness. Previous literature studies stated that the variable of safety awareness has a significant relationship with that of culture, knowledge, and behavior. It is also necessary to confirm whether the relationship between these variables applies to intercity bus drivers. This study confirmed the relationship between the safety culture variables among the intercity bus operators and their safety knowledge, behavior, and awareness. The results showed that safety culture improvement helped in the development of knowledge. Besides, increasing the knowledge variable caused an improvement in behavior, which develops safety awareness. The three top factors that caused significant improvement were (1)Provision of adequate fuel supply before bus operation, (2)Providing appreciation in rewards and promotions for drivers who had worked hard to maintain safety while driving, (3)Management should collaborate with contractors for maintenance and repairs, tire supply, and bus washing. A 1-point increase in the performance of the culture variable leads to a rise in the efficiency of safety awareness by 0.679.