The Philippines is a developing country in which technological innovations and digital interventions shaped and deepened the gap in the need for better healthcare services for Filipinos. The focus of this study is to identify the factors in the use of telemedicine that affects the satisfaction level of the Millennial and Generation Z telemedicine users in the Philippines. A total of one hundred thirty-eight (138) respondents from Millennials and Generation Z individuals in the Philippines answered the survey questionnaire and data were analyzed with the use of multiple regression analysis. The Millennials have five (5) factors that contributed to the satisfaction towards telemedicine such as usefulness, reliability, salary, ease of use, and employment status. Moreover, Generation Z has four (4) factors such as usefulness, interaction, salary, and period of use. According to the findings, Millennials have a score of 33.17 while Generation Z has a 35.85 score which corresponds to a strong telemedicine satisfaction. With this result, the study recommends to Information and Computer Technology, healthcare practitioners as well as the healthcare industry to develop ways to improve telemedicine services to sustain the growing demand to meet the needs of the generational gap for better healthcare delivery in the Philippines.