This study analyses the impact of technology capabilities and innovation ambidexterity on the MSMEs business resilience. Structural Equation Modelling was used as an analytical technique involving 400 MSMEs in Bandar Lampung that were selected using a simple random sampling technique. This study employs a quantitative approach by distributing a six-point questionnaire on a Likert scale with 33 questions. The results showed that technological capabilities and innovation ambidexterity had a positive and significant effect on the business resilience. Furthermore, technology capabilities also have a positive and significant impact on innovation ambidexterity. Innovation ambidexterity plays a mediating role in the relationship between technological capability and business resilience. This research can serve as information for MSME owners to enhance their business resiliency. In addition, this research may also provide insight into technology capabilities, innovation ambidexterit, and business resilience.