This article aims at prioritizing and analyzing the enablers that supports implementation of Lean Six Sigma with sustainability considerations. 10 such crucial enablers were identified and an integrated Interpretive Structural Modeling (ISM) and MICMAC (Matriced’ Impacts Croisés Multiplication Appliqués à un Classement) approach was applied for prioritizing the enablers. Based on the analysis, the most dominant and dependent enablers that enables LSS adoption with sustainability considerations were identified. The enablers, namely, “Availability of proper defect monitoring system, Availability of well designed roadmap for sustainable LSS Implementation and Effective in-bound and out-bound communication”, occupy the base segment of the ISM hierarchy; the enabler, namely, “A supportive Leadership”, occupy the top level of the ISM hierarchy. The study helped in identifying and prioritizing the enablers that supports LSS adoption with sustainable considerations arrived using a mathematical approach. This approach will be helpful for practitioners and implementation experts to focus on enabling the key dominant enablers and to deploy LSS adoption with sustainable considerations.