Mobility is always been an important and integrated part of human civilization. It supports social, cultural, & economic interaction. However, amid the COVID-19 pandemic, mobility has been restricted due to fear of coronavirus, and therefore home delivery services started playing a vital role in contributing to economic activities. That led to manifold growth of the E-commerce business. This has significantly affected urban mobility and travel demand.  And it is safe to believe that this e-commerce approach will continue to grow even after the pandemic situation gets over. Furthermore, the concept of Industry 4.0, IoT, & ICT will definitely have some role to play in E-commerce and, therefore, in urban mobility. This paper discusses, at a conceptual level, a number of issues related to E-commerce, transportation, Industry 4.0, IoT, & ICT along with logistics and supply chain. This study is important from a futuristic point of view as the future looks more toward an automated internet-based approach, and mobility, transportation, and logistics cannot remain un-impacted by this. Therefore a possible integrated model for passenger metro train and last-mile parcel flow of E-commerce deliveries has been proposed. This study is concentrated on Nagpur urban area and focused on developing a working methodology to understand the concept of Industry 4.0, IoT, ICT, and E-commerce on transportation and mobility.