A work accident is an incident when a worker is at work that causes injury or health problems. According to the Indonesian Ministry of Industry's Data and Information Center (2019), Work accident cases in several companies in Indonesia in 2018 were 173,105 people. The death rate due to work accidents was 5318 people. The tissue company has several machines because it produces many types of tissue. The facial engine produces tissue for the face, while the napkin machine produces tissue to eat or place on the dining table, and the rolling machine produces tissue placed on the toilet. The number of production processes makes the level of risk of work accidents and occupational diseases have a high probability. The number of work accidents fluctuates and is influenced by occupational safety and health. This study aims to determine the factors that cause work accidents and eliminate the risk of harm in work activities in the HIRADC form.  The research method used is qualitative. The primary data of this study were obtained from distributing questionnaires to 150 employees who work in the production area, interviews, and the results of focus group discussions. Testing this research hypothesis by testing the validity and reliability using SPSS software, the method used in this study is the PDCA method and uses the HIRADC form. Three indicators cause work accidents: SOPs, work environment, and work programs.