The research objective was to measure and analyze work ethos and experience on employee performance through job satisfaction at the Regional Secretariat Office of Central Mamuju Regency. This research was carried out at the Regional Secretariat Office of Central Mamuju Regency. The sampling technique was purposive sampling. The total population was 47 employees because of its nature. Saturated, then the entire population is used as a sample. The analysis tool used is path analysis using SPSS version 23.0 software. The results show that: (1) work ethic has a significant positive effect on the Regional Secretariat of Central Mamuju Regency, (2) Work ethic has a significant positive impact on the Regional Secretariat of Central Mamuju Regency Work experience,  It has no significant positive effect on the regional Secretariat office of Mamuju Regency, (3) Job ethos has a significant positive impact on employee performance through job satisfaction of the Regional Secretariat of Central Mamuju Regency, (4) Work experience has an insignificant negative effect on employee performance through job satisfaction of the Regional Secretariat of Central Mamuju Regency, and (5) Job satisfaction has a negative and negligible impact on the Regional Secretariat's performance of Mamuju Regency.