The current outbreak of the Coronavirus diseases that have constituted a global issue with its adverse effects upon the world economy, healthcare systems, human lifestyle, and educational system. Several thousands of lives have was; numerous business establishments have folded up. This disease outbreak has been accompanied by a high mortality rate and loss of employment across the nations of the world. Several challenges have arisen from the recent epidemic of coronavirus pandemic. Over the years, nanomaterial has been used considerably in address the numerous clinical and health system challenges. This paper aims to carry out a comprehensive and systematic review of existing literature, investigates how nanomaterial and nanotechnology can aid in addressing the challenges of this outbreak and the current mitigation approaches. In this study, we explore the role of nanomaterial in addressing the challenges: supply of personal protective equipment, reliable clinical diagnostic, vaccine development, and therapeutic drugs. Covid-19 trial affords nanomaterial with the vast opportunity to exhibit their vital contribution to the healthcare system at this time of great need.