Industry 4.0 is characterized by the use of several technologies used individually or interconnected, this model contributes to process optimization and waste reduction. Within the manufacturing industry, the Brazilian textile and clothing industry stands out for its high employability rate and for being the largest integrated production chain in the West, from the production of fibers, such as cotton plantation, to fashion shows (ABIT, 2018). In Brazil, the textile industry is disseminated throughout its territory with a high concentration in the state of Santa Catarina, standing out as a textile pole. Based on this, this multi-case study aims to explain and compare the results of applying the questionnaire regarding the use of technologies from industry 4.0 in four textile industries in the region of the State of Santa Catarina. The most used technologies in companies are cyber security, big data, systems integration and internet of things (IoT), the last three being considered more relevant to the industry, in addition to simulation, according to the research result. Investment in new technologies, lack of qualified labor, change to a New Business Model and standardization, were listed as main barriers for the implementation of industry 4.0.Industry 4.0 is characterized by the use of several technologies used individually or interconnected, this model contributes to process optimization and waste reduction. Within the manufacturing industry, the Brazilian textile and clothing industry stands out for its high employability rate and for being the largest integrated production chain in the West, from the production of fibers, such as cotton plantation, to fashion shows (ABIT, 2018). In Brazil, the textile industry is disseminated throughout its territory with a high concentration in the state of Santa Catarina, standing out as a textile pole. Based on this, this multi-case study aims to explain and compare the results of applying the questionnaire regarding the use of technologies from industry 4.0 in four textile industries in the region of the State of Santa Catarina. The most used technologies in companies are cyber security, big data, systems integration and internet of things (IoT), the last three being considered more relevant to the industry, in addition to simulation, according to the research result. Investment in new technologies, lack of qualified labor, change to a New Business Model and standardization, were listed as main barriers for the implementation of industry 4.0.