Continuous quality improvement is one of the keys for business success as well as business problem solving. Six Sigma is the most recognized and perceived quality change technique. Six Sigma can be defined as a statistical measure of variability which is the cause of defective and out-of-control processes. In this paper, six sigma was utilized to eliminate duplex gluing defects in cartoon production at Noor company. The number of defectives has been successfully decreased after identifying and changing the level of three factors were found to be the reason behind the increasing defective units. These factors are speed, amount of pressure applied to fix glue, and how long the pressure time.