Learning difficulties experienced by students are basically a reflection of their learning efforts. In general, the less learning effort you have, the greater the learning difficulties you will experience. Many factors affect learning difficulties, including interests, motivation, parental support, parental income levels, and so on. This paper aims to analyze the difficulties in learning mathematics among students in Bandung. Factors that are thought to influence mathematics learning difficulties include interest, motivation, parental support, parents' income levels, and the number of dependent children of the parents. The population in this study is students from various universities in the city of Bandung. Data were collected by random sampling techniques, using a questionnaire to 100 respondents. The data analysis technique used descriptive statistical analysis and inferential statistical analysis. The results of inferential statistical analysis show that interest (X1), learning motivation (X2), parental support (X3), parents' income level (X4), and the number of dependent children (X5) together have an effect on mathematics learning difficulties. student (Y) in the city of Bandung, which is indicated by the F-count value of 11.275 is greater than the F-table value of 2.30. The pattern of influence between these six variables is expressed by the multiple regression equation.