Lean six-sigma as quality improvement tool is widely gaining attention in the optimization of production process in manufacturing industries as it helps to trim down waste. The work aimed at improving down time as manufacturing waste in a Paper Company. The analysis of the production process was done using Pareto analysis, Overall Equipment Effectiveness indicator and cause and effect analysis which revealed the down time problem, traceable to high rate of setup time and changeover of order due to incessant ink wetting, plate misalignment of the printing machines and other factors related to work organization. Lean six sigma tools of Single Minutes Exchange of Die and 5S techniques were implemented and these reduced the down time from 32. 6 to 11% and therefore increase customer satisfaction.