The current COVID-19 pandemic has shifted the lifestyle of people from education, business, and even the healthcare service. There is a rise in telemedicine utilization among different countries. Third world countries such as the Philippines have been seen to consider telemedicine, however not as widely applied. The aim of this study was to determine the factors affecting the acceptance and behavioral perception of Filipinos on the adaptation and usage of telemedicine in the Philippines. A total of 533 Filipinos answered an online survey that was collected through different social media platforms. Using multiple linear regression, factors under the unified theory of acceptance and use technology, personal factors, individual factors, and political and environmental factors were considered. With 96.53% R-square value, the results posit that age, geographic location, data privacy issue, resistance to use, usage behavior, intention to use, effort and performance expectancy, and hedonic motivation were the key factors affecting perceived user adaptation. The employment status modelled the regression equation considered in this study. The findings of this study would be advantageous for developing strategies to increase the adaptation among Filipinos for telemedicine. The healthcare system in the Philippines may adopt the findings of this study to increase Filipino trust and usage behavior. Lastly, the results and latent of this study could be utilized by other developing countries who wants to increase adaptation and usage of telemedicine, even evaluate technology usage worldwide.