Productivity is not just about doing more, it is about creating more impact with less resources, and it can be achieved only by intelligent planning and sustained hard work. Employee productivity play a vital role in any organization, it is biggest challenge to sustain with low operating cost and manpower cost with high profit margin in such competitive environment. This paper illustrate the journey to improve employee productivity and resource optimization approach in a pharmaceutical industry. The entire exercise consists study of existing process and manpower deployment pattern, identify the redundancy and bottlenecks in the current system, manpower benchmarking and comparison exercise and proposed standard manpower with skill enhancement framework. Industrial engineering tools and techniques being applied in the data collection and process mapping exercise. Study has been conducted in the pharmaceutical processes like- Granulation, Compression and Coating and packaging. This paper also includes a skill enhancement framework to make the operatives’ multi skilled, thereby allowing them to work in different departments flawlessly.