Industry 4.0 provides many unique challenges for business leadership. The volumes of data availability reside in numerous locations, which were not even in existence a decade ago. The affordability of huge data storage and the new techniques of gathering data are resources that are in the nascent stages of development. Within this new data frontier exists the human element of the business world. Automation and artificial intelligence have replaced many repetitive jobs, while the need for knowledge workers continues to develop. The opportunities to apply innovation through the analysis and application of data are limitless. Leadership must provide a method for taking advantage of the data, while developing their employee’s skills to become knowledge workers. This transition of employees to knowledge workers can be accomplished by specific application of several elements of the existing Quality Body of Knowledge. A knowledge worker, as a member of a high performing team, is able to provide contributions to companies in their pursuit of organization excellence.