While selecting the most appropriate interchange type is a major concern that transport and traffic experts are dealing with, one of the essential questions that repeatedly appears on the table is how to select the best interchange based on the contributing criteria. In the present study, the influencing factors on selecting interchange type are extracted by Delphi method followed by their clustering utilizing card sorting technique to the environment, safety, cost, executive constraint, regional, geometric characteristics, and traffic, and eventually applied the multi-criteria decision-making process of Dematel to select the best interchange type. The well-known intersection of Sanaat Square in the Iranian capital of Tehran has been selected as a case study and the proposed procedure performed by receiving experts’ opinions. After validating the proposed procedure, the results revealed that land use, accident reduction rate, domestic interchange construction experience, noise pollution reduction, distance to adjacent interchange, and construction cost are the main factors that play significant roles in interchange type selection for interchange.