Climate Change is a major threat to sustainable development and growth in Africa, and more especially in Nigeria and the achievement of Millennium Development Goals (MDGs). The consequences include intensified desertification, flood disasters, degradation of land, erosion and the rise in tidal water along coastline. Thus, the understanding of Climate Change and the use of mathematical programming can help to deal with the complex constraint and parameters in order to manage the factors responsible for climate change in Nigeria. Furthermore, intensive efforts and realistic approach towards minimizing these factors according to the relative optimal solutions from this paper will have to be adopted in order to adequately manage climate change for economic growth and development. The aim of this article is to apply operational research methodology in managing factors responsible for climate change. Computer software – LINGO 17.0, was used to solve the resulting initial tableau derived from the Linear programming standardized model. The results show that in order to minimize climate change in Nigeria, the most important factor in transportation related. So, more money should be spent on transportation system in order to combating climate change in Nigeria.