Industry 4.0 has evolved from a perception of smart factories to include value chain (i.e. manufacturing, production, logistics, supply chain and Internet of Things (IOT)). Many companies are leading the transformation toward Industry 4.0 based on innovation by Cyber-Physical System (CPS). CPS Systems integrate computation, networking and physical processes that will provide new functionalities to improve quality of life and enable technological advances in critical areas. Besides CPS, transformative technologies impacting Industry 4.0 are Machine-to-machine learning, Big-Data analysis, Cloud computing, Mobile internet, Autonomous vehicles and advanced materials. Industry 4.0 is also influenced by extensive application of Enhanced Visualization and Simulation, Additive Manufacturing, Smart Automation and Augmented Reality. The combination of Internet technologies and future-oriented technologies in (machines & products) based on advanced digitalization results in a new fundamental paradigm shift in Industry. This paper includes a case study demonstrating the impact of Industry 4.0 - including the integration of CPS in Human Balance and Rehabilitation Engineering. Growing heath care needs have seen the introduction of Artificial intelligence and data science integrated to tele-sensing of vital signs. Sensory perception and model based decision making has helped the study of human gait to assist in balance.  This case study involves impaired populations involving stroke survivors, fall-prone elderly, vestibular loss sufferers and amputees using an ambulatory suspension system. The case study demonstrates the use of sensory perception, data collection and the use of body support system such as an Ambulatory Suspension System for decision making on balance. These technologies are reordering the global industry structure, creating new markets, products, improving labor productivity and driving growth in advanced economies. These technologies have enormous impacts on predictive maintenance, improved decision-making in real time, real time inventory and improved flexibility among jobs.