Apparel manufacturing industry is facing gigantic issue to meet customer demand and make them happier due to improper supplier selection. Factory does not follow the scientific and analytical techniques to select the right supplier .In this paper, we have done the right supplier selection by implementing cross-over and mutation analysis of genetic algorithm. Moreover, criteria based analysis also been done to get the right supplier at the real time. Furthermore, supply chain optimization experiment has been done with DOE-Taguchi method. Industry can save up to 30 % of their total cost by selecting right supplier.