As the labor cost increasing day by day in the garments manufacturing industry so there is no alternative way to optimize the supply chain to maximixe the profit and retain in the competitive market. In this research, we have been implemented ANN to optimize the apparel supply chain . Furthermore, we have been implemented an found out the precise way of selecting the right supplier at reall time to attain best possible optimization in the supply chain . Meanwhile, supply chain optimizatioin is crucial to cut the cost from diffrenet echelon of the supply chain . In this research, we have seen that minimum 25 % of the profit intensity trough the supply chain optimization.