The increase in the Covid-19 case in Indonesia is increasingly troubling, for this reason the Government of Indonesia adopted a policy to issue Presidential Decree No. 11 of 2020 concerning Determination of the Covid-19 Public Health Emergency. In addition, the Government developed a Grand Strategy for Handling Covid-19. In South Kalimantan the Covid-19 case has been confirmed since March 22, 2020, based on this the South Kalimantan Provincial Government issued a policy through the Decree of the Governor of South Kalimantan Number 188.44 / 0210 / KUM / 2020 concerning Limitation of Inflows of People Coming in from Outside the Province of South Kalimantan. But in practice there are various obstacles. This brief review was conducted to determine opportunities and constraints and challenges in handling Covid-19 using a SWOT analysis. Secondary data retrieval is done by scientific search and literature studies. Scientific search based on data requirements that can be obtained at government agencies and online data search. Literature study is conducted to interpret and describe data that can support the topic of this study. Based on the results of the analysis in handling Covid-19 required quarantine of ODP, implementation of structured PSBB, fulfillment of facilities and infrastructure, education about Covid-19 and coordination between related sectors.