The Philippines’ readiness to participate with the fourth industrial revolution (Industry 4.0) is highly imminent through incorporating science and technology aspects to the MSMEs’ overall operation. This study aims to assess the impact of SETUP implementation at the regional level, particularly in regions NCR, III, and XII based on the criteria from national SETUP guidelines. In this context, the Analytic Hierarchy Process (AHP) Model was used in determining the weights of the performance indicators under the defined SETUP criteria. The weights of the six (6) performance indicators under the three main criteria were computed through AHP to determine the overall impact of SETUP to MSME beneficiaries- highest and lowest impact. Analysis of the pairwise comparison matrix reveals that technology, process, and innovation assimilation (criteria 1) has the highest computed weight with 59.30% while entrepreneurial acumen and management leadership (criteria 3) follows the market and financial outcomes (criteria 2) with 12.60% and 27.10% respectively.  For the impact assessment, Region XII has the highest computed scores for criteria 1 and criteria 2, while the highest IA score was observed in NCR for criteria 3. Further, the highest impact scores were observed on the single-proprietorship businesses engaged in agriculture/marine/aquaculture, and food processing.