COVID-19 is an serious, deadly infectious disease that is hard to cure. It’s caused by a newly discovered coronavirus. As of today, there are about 2.5 million confirmed COVID cases with a high increasing rate. And numerous reports have stated that anywhere between 25-50% of cases are asymptomatic. Asymptomatic cases can be attributed to the rapid spread of COVID because they can also infect other healthy people. At this time, there are no specific vaccines or treatments for COVID-19. As a result, the diagnostic tests of COVID-19 is very important to people. There are already a few kinds of different tests, but they have some different kinds of defects. For example, the detect time is very long that it may take a few days. During these days the patient may have already went to some public places and spread the virus to others. My research was trying to develop another new kind of detection method for SARS-CoV-2’s RNA by using the Magiprobe. I first use NCBI dataset found segments of sequences from the open area of the RNA which forms SARS-CoV-2. Then, translate them into their complementary sequence. After that, by using Linux, I tested the kcal value of different probes, both against human and against the virus. Lower the value is, more correct the test probe is. After comparing all of them, I can find the lowest value of the probes and that’s the best test probe in this group. This test may be faster and cheap to reach the same target. In theory, when the target sequence is matched, the probe will have fluorescence. Of course, more research is also needed to be down in order to find the best part.