Patient safety is considered as one of the crucial aspects of the healthcare sector that required improvement. Earlier studies show the high rate of harm to patients and financial losses. In order to improve patient safety, various tools and methods were adopted from other safety-critical industries. While Prospective Hazard Analysis (PHA) tools has proven its effectiveness to enhance the safety and quality of systems and processes in others, now they also gained increased attention in healthcare. One example is the Hazard and Operability (HAZOP) technique to systematically and comprehensively identify hazards and deviations of a system from the intended design in the healthcare sector. The aim of this study is to review HAZOP and identify the potential contribution and challenges of this tool in the healthcare field, in particular patient safety context.