Industry 4.0 (I4.0) is a paradigm based on connectivity, real-time information flows, and decentralized decision-making processes. Lean is a traditional management practice that aims to promote processes that can increase value and minimize waste. Despite these practices appearing in different ages, and with different motivations, the mission that guides them culminates in the same purpose - to increase the level of operational and organizational efficiency. Information Systems (IS), particularly MES and ERP systems, in addition to representing ISs of choice for I4.0, represent data aggregating systems and facilitators of standardization and automation of the processes inherent to these two practices (Lean and I4.0). The present work, based on the literature review, proposes a Lean 4.0 shop floor framework with the main bilateral effects between Industry 4.0 and Lean, based on the challenges established by I4.0 and with the contribution of IS